Physicochemical Study of Antioxidant Surfactant Interaction: utilization in clotrimazole topical formulation;
Institution: | Jaypee University of Information Technology, Solan |
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Department: | |
Year: | 2015 |
Keywords: | Antioxidants; Clotrimazole; Formulation; Micellization; Physicochemical Interaction; Surfactants |
Record ID: | 1212531 |
Full text PDF: | http://shodhganga.inflibnet.ac.in/handle/10603/37532 |
Micellar systems hold excellent drug delivery applications due to their capability to solubilize a large number of hydrophobic and hydrophilic molecules In this present work, the mixed micelle formation between three surfactants SDS, CTAB and Triton X 100 and two synthetic lipophilic antioxidants BHA and BHT have been studied in different alcohols and hydroalcoholic mediums ie 100percent 70 percent and 30 percent of MeOH, EtOH and 1 PrOH Early micellization was found with critical micelle concentration CMC shifting towards lower concentration In this context, conductance study, CMC, standard thermodynamic parameters of micellization namely , and have been evaluated at different temperatures Molar volume and compressibility measurements have also been carried out to evaluate the apparent molar volume and#61542;v and apparent molar adiabatic compression and#61542;k of BHA BHT surfactant complex and discussed in terms of the solute solute and solute solvent interactions newline%%%