AbstractsBiology & Animal Science
Signaling Pathways in Cancer: a Matter of Dosage
| Institution: | Erasmus University |
|---|---|
| Department: | |
| Year: | 2009 |
| Keywords: | Apc; beta-catenin; cancer; dosage; mammary gland; wnt |
| Record ID: | 1249303 |
| Full text PDF: | http://hdl.handle.net/1765/14964 |
Abstract
abstractThe main issue addressed in this thesis is how different levels of signaling activity of the Wnt and TGF-β/BMP pathways can affect transcriptional responses in particular relevant for self-renewal and differentiation both in homeostasis and in cancer. Chapter 1 presents an overview of the existent literature leading to the formulation of the hypothesis that Apc/Wnt pathway acts in a dosage-dependent manner both in normal and neoplastic tissues.text
