Developing Glycopeptide based nanocarriers by ring opening polymerization for drug delivery applications

by Mohammad Nazmul Hasan

Institution: Uppsala University
Year: 2014
Keywords: Ring opening polymerization; N-Carboxyanhydride; Glycopeptide; Hyaluronic acid; Glycoseaminoglycan; Polymeric nanoparticle; Cancer treatment.; Natural Sciences; Naturvetenskap; Natural Sciences; Chemical Sciences; Polymer Chemistry; Naturvetenskap; Kemi; Polymerkemi; Materials Chemistry; Materialkemi; Organic Chemistry; Organisk kemi; Masterprogram i kemi; Master Programme in Chemistry; Kemi; Chemistry
Record ID: 1337107
Full text PDF: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233891


Synthetic glycopeptides have attracted much interest in the biomedical field due to their structural similarities to the natural glycopeptides or glycoproteins. It is still difficult to synthesize glycopeptides with greater efficiency and ring opening polymerization remains an effective way to do so. Proteoglycans are a special class of glycoproteins with glycosaminoglycan chains. In this study, I tried to do controlled ring opening polymerization of Hyaluronic acid derivatives with smaller to higher molecular weight while avoiding side reactions. It is challenging to work with higher molecular weight molecules and do a click reaction in water effectively. Making nanopolymers with a desired size, studies of the characteristics, and how to build nanocarriers for drug delivery application was the focus of this work. Polymeric characteristics, e.g., modification and polymer formation were studied by nuclear magnetic resonance technique; Particle size was studied by dynamic light scattering and the loading of rhodamine B encapsulated into the polymer was measured by confocal imaging technique.