AbstractsChemistry

Newly Designed HNO Triggered Prodrugs

by Wenrui Su




Institution: Wake Forest University
Department:
Year: 2016
Keywords: HNO
Posted: 02/05/2017
Record ID: 2065016
Full text PDF: http://hdl.handle.net/10339/62644


Abstract

Nitric oxide (NO) is an important species in many biological processes. The one-electron reduced and protonated derivative of NO, HNO has also been determined to play important biological roles. Because of HNO’s high reactivity, its detection has been difficult and many methods including fluorescent copper compounds and electrochemical methods have been devised. Our group has studied HNO for many years and recently developed a detection method based on HNO’s reaction with organophosphorus compunds.