Newly Designed HNO Triggered Prodrugs
Institution: | Wake Forest University |
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Department: | |
Year: | 2016 |
Keywords: | HNO |
Posted: | 02/05/2017 |
Record ID: | 2065016 |
Full text PDF: | http://hdl.handle.net/10339/62644 |
Nitric oxide (NO) is an important species in many biological processes. The one-electron reduced and protonated derivative of NO, HNO has also been determined to play important biological roles. Because of HNO’s high reactivity, its detection has been difficult and many methods including fluorescent copper compounds and electrochemical methods have been devised. Our group has studied HNO for many years and recently developed a detection method based on HNO’s reaction with organophosphorus compunds.