Experimental Investigation and Modeling of Growth Cone Adaptation in the Development of Topographic Projections (Experimentelle Untersuchung und Modellierung der Wachstumskegel-Adaption bei der Entwicklung topographischer Karten)
Institution: | Universität Karlsruhe |
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Department: | |
Year: | 2016 |
Posted: | 02/05/2017 |
Record ID: | 2134221 |
Full text PDF: | http://digbib.ubka.uni-karlsruhe.de/volltexte/documents/3875880 |
In the visual system, retinal ganglion cell growth cones (GCs) map topographically onto the optic tectum in the midbrain. Gradients of EphAs and ephrin-As along both, the retinal temporonasal and the tectal anteroposterior axes provide the chemoaffinity cues guiding retinal GCs to their topographically appropriate tectal destinations. Topographic precision is thought to rely on a faithful read-out of guidance cue concentrations, in this work, however, I show that GCs can adapt towards both cues.