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Molecular heterogeneity and angiogenesis in glioblastoma

by Siobhan Conroy



Abstract

Het doel van dit proefschrift was het onderzoeken van de moleculaire diversiteit en de de rol van angiogenese in glioblastomen van verschillende moleculaire subtypen. De kenmerken van transcriptionele subtypen werd bestudeerd door deze initieel op eiwitniveau te definiren, en vervolgens door de kinase activiteit en vaatpatronen te onderzoeken. De plasticiteit van deze subtypen is tevens onderzocht, en het tweede deel van het proefschrift richt zich op de rol van angiogenese in algemene zin, en wordt afgesloten met onderzoek naar de mate waarin dit compartiment therapeutisch te benaderen is.Advisors/Committee Members: Timens, Wim, Kruyt, Frank, Dunnen, den, Wilfred, Bhat, K. P., Kros, J. M., Wesseling, P., Groen, Rob, Pathology & Medical Biology: Pathology.

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