AbstractsMedical & Health Science

Dual paclitaxel/superparamagnetic iron oxide-loaded PLGA-based nanoparticles for cancer therapy and magnetic resonance imaging

by Nathalie Schleich

Institution: Université Catholique de Louvain
Department: Louvain Drug Research Institute
Year: 2015
Keywords: Cancer; Targeted drug delivery; MRI; Theranostic; Magnetic targeting; Nanomedicine
Record ID: 1074744
Full text PDF: http://hdl.handle.net/2078.1/156338


Theranostic nanoparticles (NP) have the potential to revolutionize cancer diagnosis and therapy. We aimed to develop dual paclitaxel/SPIO-loaded PLGA-based NP for cancer therapy and magnetic resonnance imaging. In the first part we prepared and characterized these mutfifunctionnal nanoparticles. We demonstrated their in vitro efficacy as T2 contrast agent, their significant cellular uptake by CT26 cells and in vivo anti-tumor efficacy. In the second part, we compared different targeting strategies in vivo: passive, active targeting (AT) of αvβ3 integrin, magnetic targeting (MT) and the combination of the two latest. Using Electron Spin Resonance spectroscopy and Magnetic Resonance Imaging (MRI), we demonstrated that the combination of AT and MT drastically enhanced nanoparticle accumulation into the tumor tissue, contrast in MRI and anti-cancer efficacy. Double targeting of nanoparticles to tumors could be a promising approach for therapeutic treatment and personalized therapy. (SP - Sciences de la santé publique)  – UCL, 2015