AbstractsBiology & Animal Science

Effect of combined treatment with R-(+)-methanandamide and chemotherapeutic drugs in mantle cell lymphoma and chronic lymphocytic leukemia

by Vasanthakumar Thirugnanam

Institution: Mälarden University
Year: 0
Keywords: Medical and Health Sciences; Medicin och hälsovetenskap; Medical and Health Sciences; Basic Medicine; Pharmacology and Toxicology; Medicin och hälsovetenskap; Medicinska grundvetenskaper; Farmakologi och toxikologi; Medical and Health Sciences; Clinical Medicine; Dentistry; Medicin och hälsovetenskap; Klinisk medicin; Odontologi; Engineering and Technology; Chemical Engineering; Teknik och teknologier; Kemiteknik; Agricultural Sciences; Veterinary Science; Medical Bioscience; Lantbruksvetenskaper; Veterinärmedicin; Medicinsk biovetenskap; MEDICINE; MEDICIN; MEDICINE; Physiology and pharmacology; Pharmacological research; Pharmacology; MEDICIN; Fysiologi och farmakologi; Farmakologisk forskning; Farmakologi; ODONTOLOGY; Biochemistry; ODONTOLOGI; Biokemi; TECHNOLOGY; Chemical engineering; TEKNIKVETENSKAP; Kemiteknik; VETERINARY MEDICINE; Biochemistry and clinical chemistry; VETERINÄRMEDICIN; Biokemi och klinisk kemi; Kemiteknik; fysik/kemi/matematik; fysik/kemi/matematik
Record ID: 1368816
Full text PDF: http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-4876


Mantle cell lymphoma (MCL) is a non-Hodgkin B-cell lymphoma with very bad prognosis. The genetic hallmark of MCL, is the translocation t(11;14)(q13;q32) which leads to overexpression of cyclin D1, a D-type cyclin that is not usually expressed at high levels in normal B lymphocytes.   Previous studies indicate that cannabinoid receptors are expressed in lymphoma and have shown that lymphoma cell death is induced as a result of exposure to cannabinoids (ligands).   The aim of this diploma work was to combined cytostatics with the cannabinoid receptor ligand R (+)-Methanandmide (R-MA). Our data suggest that combination treatment with cytostatics and R-MA induces synergistic effects in most cases.