AbstractsBiology & Animal Science

Glomerulonephritis produced in rabbits by massive injections of foreign proteins.

by Douglas. Waugh




Institution: McGill University
Department: Department of Pathology.
Degree: PhD
Year: 1950
Keywords: Pathology.
Record ID: 1501266
Full text PDF: http://digitool.library.mcgill.ca/thesisfile124211.pdf


Abstract

The experiments to be reported in this treatise were carried out with the object of contributing to the general knowledge of the human disease, acute diffuse glomerulonephritis. Albino rabbits were used in all experiments. These animals exhibit many important anatomical and physiological differences from humans. It is therefore obvious that any findings reported will depend for their ultimate validity upon the demonstration that, in certain respects at least, rabbits are capable of responses similar to those of humans, and vice versa. Limitations of time and material resources have not permitted the work to reach this decisive point. Thus, any equivalence existing between the experimental disease in rabbits and the natural disease in humans will have to be reached via deduction, which must, itself, be based upon knowledge of the human disease and its presumed experimental counterpart. The various aspects of human glomerulonephritis will, therefore, be considered in some detail before discussion of artificially induced nephropathies in rabbits is entered.