AbstractsBiology & Animal Science

Tumour tissues in vitro show an incorporation of glucose carbon into glycine, alanine, glutamate and aspartate. The incorporation into glutamate and aspartate is lower than that observed in normal rat brain cortex slices or chick embryo. This may be due to a lower rate of operation of the citric acid cycle compared with that of glycolysis in tumours. When normal rat brain cortex slices are incubated with tumour tissues in vitro, in a medium containing 5 mM 14 glucose-U-C14, there is a decrease in the amount of glutamine found in the brain cortex slices, with a concomitant increase in the incorporation of glucose carbon into glutamate, aspartate and alanine of the tumour tissues.