AbstractsMedical & Health Science
A clinical and electroencephalographic evaluation of local anesthetics injected via the carotid artery on penicillin and strychnine seizure activity in the cat and monkey.
| Institution: | McGill University |
|---|---|
| Department: | Department of Health Sciences. |
| Degree: | MS. |
| Year: | 1964 |
| Keywords: | Neurology and Neurosurgery. |
| Record ID: | 1579539 |
| Full text PDF: | http://digitool.library.mcgill.ca/thesisfile115346.pdf |
Abstract
Procaine was first synthesized by Einhorn in 1905. Xylocaine (Lidocaine) was synthesized by Löfgren in 1948. Wiedling, Löfgren and Tegner reported on Propitocaine (Citanest) in 1960. They have been used mainly for local and regional anesthesia in surgery and dentistry. The first review of the use of local anesthetics by the intravenous route was reported by Graubard and Peterson in 1950. Gilbert et al (1951) reported similar results using intravenous Xylocaine. In their cases they reported effective analgesia when the Xylocaine was used in cases of advanced cancer. They reported that the danger of side-effects appeared to be less than with Procaine.
