Experimental metabolic alkalosis in the dog.
Institution: | McGill University |
---|---|
Department: | Department of Health Sciences. |
Degree: | MS. |
Year: | 1964 |
Keywords: | Investigative Medicine. |
Record ID: | 1582289 |
Full text PDF: | http://digitool.library.mcgill.ca/thesisfile115501.pdf |
The first significant study of biochemical changes which accompany vomiting or gastric succion in animal or man was made by Gamble in 1925 (31). Although a few predecessors had observed the therapeutic effect of sodium chloride infusions in such experimental situations, (37, 38, 51) Gamble first demonstrated that blood alkalosis was a major alteration secondary to loss of gastric juice and studied the corrective effect of acute sodium chloride infusion. His data have been amply confirmed by certain of his contemporaries and a number of subsequent works (35, 43, 3a, 10, 15, 36, 44, 46, 47, 67, 78, 22).