AbstractsBiology & Animal Science

The genetics and pathogenesis of a hereditary cataract in the mouse.

by A. Carl. Verrusio

Institution: McGill University
Department: Department of Genetics.
Degree: MS.
Year: 1964
Keywords: Genetics.; Cataract.; Mice.
Record ID: 1584374
Full text PDF: http://digitool.library.mcgill.ca/thesisfile116721.pdf


Cataract has been defined by Bourne as any pathological condition of the lens which alters its normal transparency. More specifically, a cataract is regarded as a loss of transparency of the lens, or an opacification occurring at any place in the lens or its capsule. Since the lens is an intricate physico-chemical system, changes in the physical and chemical state of the lens proteins which result in loss or transparency or opacification may be brought about by many agents: interference with the normal metabolic processes, alteration in hydrogen ion concentration, disturbance of osmotic equilibrium, and the harmful action of heat, light, and radiation. As a result, cataract presents many complexities with respect to clinical manifestations. [...]