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Integrated analysis of miRNA expression in response to Salmonella Typhimurium infection in pigs

by Uribe Juber Herrera

Institution: Universidad de Crdoba, UCOPress
Year: 2017
Keywords: MicroRNAs; miRNAs; Salmonellosis; Salmonella Typhimurium; Pigs; Animal genetics; Animal pathology; Salmonelosis; Cerdos; Gentica animal; Patologa animal
Posted: 02/01/2018
Record ID: 2154373
Full text PDF: http://hdl.handle.net/10396/14637


Abstract

La salmonelosis es una enfermedad gastrointestinal causada por S. Typhimurium, la cual es transmitida mediante ingesta de comida de origen animal contaminada. Se considera un problema grave de salud pblica, y la carne de cerdo es uno de los reservorios ms importantes de la enfermedad. Como el cerdo es considerado un buen modelo animal para estudiar enfermedades humanas, la investigacin sobre mecanismos moleculares involucrados en la respuesta a la infeccin en cerdos es necesaria para la salud humana. Los microRNAs (miRNAs) son un tipo de RNA no codificante que interfiere con la estabilidad y traduccin de la protena. Los miRNAs regulan post-transcripcionalmente procesos biolgicos como aquellos causados por bacterias. Aunque la respuesta porcina a la infeccin por S. Typhimurium ha sido estudiada previamente, se sabe poco del papel que juegan los miRNAs en la regulacin gnica y expresin de protenas durante la infeccin. Por tanto, el objetivo de este estudio fue la identificacin los miRNAs que regulan la respuesta a la infeccin por S. Typhimurium en el tracto gastrointestinal y ndulo linftico mesentrico porcino, usando herramientas micas de nueva generacin.Advisors/Committee Members: Garrido Pavn, Juan Jos, Zaldvar-Lpez, Sara.

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