Abstracts Category : Other

Add abstract

Want to add your dissertation abstract to this database? It only takes a minute!

Search abstract

Search for abstracts by subject, author or institution

Share this abstract

Identifying functional adaptations associated with pathogenicity in bacteria.

by Nicole E Wheeler

Institution: University of Canterbury
Year: 2017
Posted: 02/01/2018
Record ID: 2198426
Full text PDF: http://hdl.handle.net/10092/13713


Abstract

Next generation sequencing technologies have provided us with a wealth of information on geneticvariation, but predicting the functional significance of this variation is a difficult task. This thesissummarises the development of a profile hidden Markov model based approach we call deltabitscore(DBS). The approach identifies orthologous proteins that have diverged at the amino acid sequencelevel in a way that is likely to impact biological function. I present the benchmarking of this approachusing several widely used datasets and its application to various biological questions. I then outlinethe extension of this method from a pairwise comparative method to one that can be scaled for thecomparison of hundreds or thousands of bacterial genomes. I demonstrate the utility of the method foridentifying associations between genetic variation and phenotypes of interest, and discussmethodological considerations and extensions that must be made in order for this approach tofunction effectively on a large scale.

Add abstract

Want to add your dissertation abstract to this database? It only takes a minute!

Search abstract

Search for abstracts by subject, author or institution

Share this abstract

Featured Books

Book cover thumbnail image
Electric Cooperative Managers' Strategies to Enhan...
by White, Michael Edward
   
Book cover thumbnail image
Bullied! Coping with Workplace Bullying
by Gattis, Vanessa M.
   
Book cover thumbnail image
The Filipina-South Floridian International Interne... Agency, Culture, and Paradox
by Haley, Pamela S.
   
Book cover thumbnail image
Solution or Stalemate? Peace Process in Turkey, 2009-2013
by Yurtbay, Baturay
   
Book cover thumbnail image
Performance, Managerial Skill, and Factor Exposure...
by Avci, S. Burcu
   
Book cover thumbnail image
The Deritualization of Death Toward a Practical Theology of Caregiving for the ...
by Gibson, Charles Lynn
   
Book cover thumbnail image
Emotional Intelligence and Leadership Styles Exploring the Relationship between Emotional Intel...
by Olagundoye, Eniola O.
   
Book cover thumbnail image
Commodification of Sexual Labor Contribution of Internet Communities to Prostituti...
by Young, Jeffrey R.
   
Book cover thumbnail image
The Census of Warm Debris Disks in the Solar Neigh...
by Patel, Rahul I.
   
Book cover thumbnail image
Risk Factors and Business Models Understanding the Five Forces of Entrepreneurial R...
by Miles, D. Anthony