Abstracts Chemistry

Synthesis and characterization of model compounds for cobalt-substituted hemocyanin

by Thomas J. Lyons

Model compounds for cobalt-substituted hemocyanin (CoHcy) were synthesized and characterized. Model compounds were 4, 5, and 6-coordinate cobalt monomers and bridged dimers. The coordinating atoms for these models were as close to three nitrogens and one oxygen as can be found in the literature because this is the ligand set of CoHcy. UV/Vis, NIR, IR and NMR spectroscopy, as well as Differential Scanning Calorimetry, were used to characterize these compounds. The following compounds were positively identified as having been synthesized: Co(amtp)(NO3)2, [Co2(tren)2(SCN)2](BPh4)2, Cs3CoCl5, Cs3CoBr5, Co(2-MeIz)4(BF4)2, Co(2-MeIz)4(ClO4)2, and [LCo2(py)4](BF4)2. The synthesis of the following compounds was unsuccessfully attempted: LCo2Cl2-2MeOH, LCo2Br2-MeOH, and cobalt-substituted carbonic anhydrase (CoCA)