Library: Health Sciences

Background: Establishing standardized Quality of Life (QOL) core outcomes in stem cell clinical trials is important to ensure (1) researchers and clinicians can make informed decisions, and (2) clinical trials use and consistently measure the same units (Clarke, 2007; Thornley & Adams, 1998). This study reviews the most common QOL methodologies, timing/frequency of the measurement, and outcomes in cardiovascular stem cell clinical trials. Methods: To identify instruments, the study reviewed MEDLINE, Scopus, and US Clinical Trials Register through September 2010, and randomized BMSC controlled...

Truth-telling about life-threatening cancer illness is a controversial matter. Few studies have explored attitudes towards truth-telling among people from migrant communities living in cultures different to their own. The purpose of this grounded theory study was to explore the perceptions of white British and British south Asian community workers within the Metropolitan Borough of Walsall as to the factors that influence truth-telling. In-depth, focused interviews were carried out with a sample of 20 key informants. A theoretical model was developed which describes the factors that lead to an...

That neuropsychological performance is impaired in patients with affective disorders is now widely accepted, and there is growing evidence that attentional dysfunction (effortful attention in particular) is one of the major impairments normally observed. The present study aimed at defining the nature of attentional dysfunction in depression by means of tests designed to measure specific aspects of attention, such as sustained, selective, focused, divided attention, etc. We also tested the effect of increasing effortful attentional demands on subjects' performance. To that end, effort level was...

Genetically modified foods present numerous ethical, environmental, health and legal challenges. This report synthesizes information from many websites, scientific journals, newspapers and books that discuss the controversy surrounding genetically modified foods. The author has attempted to show that although the future applications of agrobiotechnology appear promising, the ways in which it is currently being used and regulated should be evaluated with a healthy degree of skepticism.

The effects of attention deficit disorders seem to touch many people's lives today, and the questions surrounding this disorder are many. There is more information regarding this disorder than at any time in its history. Unfortunately, there is just as much misinformation surrounding the facts of this disorder as ever. It is the intention of this book to, in some way, unveil a few misconceptions surrounding Attention Deficit Disorders; logically, medically, and more important scientifically. By exploring the history, etiology, comorbidity and neurological diagnostic perspectives, those in ...

Recently, endurance athletes and high altitude climbers have gained access to commercially available, portable normobaric hypoxic chambers. Intermittent exposures to hypoxia in these chambers may elicit adaptations similar to those observed during acclimatization to altitude. Manufactures of these systems purport that intermittent exposures may elicit adaptations similar to those observed in response to the hypoxia of high altitude, however there have been no reports in the scientific literature that ventilatory acclimatization or alterations in cerebrovascular dynamics occur following repeate...

The impetus for this study was the need to gain a better understanding of what interaction activities in the virtual classroom affect student outcomes. The purpose was to determine which perceptions of interactions contributed to predicting student outcomes of satisfaction and future enrollment in Web-based courses, while controlling for student characteristics. The problem is that the interaction that occurs in the Web-based classroom is markedly different than what occurs in the traditional classroom setting. The study was a secondary analysis using data from 388 student evaluations of Web...

Facilitating the transition of elderly patients from the hospital setting to their pre-hospital environment is a major challenge for health care providers. Adequate discharge planning has been mandated by the Joint Commission on Accreditation of Health Care Organization (JCAHO) and the American Hospital Association (AHA). However, reports from the literature indicate that some elderly patients on Medicare may be discharged "quicker and sicker" than in the past and that care-giving family members are often not included in the discharge planning process.The problem is that elderly patients may...

This thesis is dedicated to assess the accuracy of logistic regression (LR) and artificial neural networks (ANN) in the diagnosis of calvarial lesions using computed tomography (CT). The importance of the different features needed for the diagnosis in both models is also analyzed. The models were developed using patients with calvarial lesions as the only known disease were enrolled. All patients were studied with plain films and CT. Other imaging thecniques were used when available. The clinical and CT data were used for developing LR and ANN models. Both models were tested with the jac...

Polyclonal lymphocyte activation and hypergammaglobulinemia characterize the acute phase of Chagas' disease, a debilitating condition caused by Trypanosoma cruzi. Such pathogenic hyper-reactivities not only compromise specific host defense against the pathogen, but may also contribute to infection-induced chronic autoimmune responses. Characterizing parasite-derived factors driving non-specific immune responses will provide insights for parasite evasion of host specific immunity. This study shows that T. cruzi trans-sialidase (TS) is one such polyclonal activator for normal murine lymphoid and...